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Werner syndrome RecQ helicase-IN-1
CAS No. 2869954-34-5
Werner syndrome RecQ helicase-IN-1( —— )
Catalog No. M36443 CAS No. 2869954-34-5
Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 84 | Get Quote |
|
| 5MG | 121 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 25MG | 287 | Get Quote |
|
| 50MG | 486 | Get Quote |
|
| 100MG | 761 | Get Quote |
|
| 500MG | 1701 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameWerner syndrome RecQ helicase-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionWerner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.
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DescriptionWerner syndrome RecQ helicase-IN-1 (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research.
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In VitroWerner syndrome RecQ helicase-IN-1 (example 42) has an IC50 value of 100 nM for WRN ATPase and GI50 values of 50 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number2869954-34-5
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Formula Weight702.08
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Molecular FormulaC31H31ClF3N9O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (142.43 mM; Ultrasonic )
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SMILESC(C(NC1=C(Cl)C=C(C(F)(F)F)C=C1)=O)N2C=3N(C(=O)C(=C2CC)N4CCN(C(=O)C=5C(O)=C(C)N=CN5)CC4)N=C(N3)C=6CCOCC6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060
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